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9). Title: [Use of citrulline malate (stimol) in patients with autonomic dystonia associated with arterial hypotension]

Author: Oknin, VIu; Fedotova, A. V.; Vein, A. M.

Journal: Zh Nevrol Psikhiatr Im S S Korsakova. 1999;99 (1):30-3.

PMID: 11530455

Abstract: To study possibilities of a therapeutic correction of asthenic syndrome in individuals with chronic arterial hypotension with malate citrulline, the study was made of 12 women and 3 men with psychoautonomic syndrome (autonomic dystonia), combined with chronic constitutional arterial hypotension. Their age was from 27 to 45 years (mean age–37.6). A control group comprised 14 healthy individuals. Both a state of autonomic nervous system and manifestations of arterial hyportension were analyzed by means of complex scored questionnaires. Mental condition was assessed by the tests of Spilberger (evaluation of reactive and personal anxiety) and of Beck (estimation of depressive manifestations). In all the examined individuals with chronic arterial hypotension, there was psychoautonomic syndrome combined with complaints to asthenic manifestations, namely, to low performance and fatigue. Stimol was prescribed in the form of 50% solution in daily dose of 6 g (3 administrations). The therapy resulted in regression of clinical manifestations of both psychoautonomic syndrome and asthenic symptoms. A mechanism of the drug’s action works through favourable changes in cerebral and muscular cells, that, in turn, had an influence on other manifestations of psychoautonomic syndrome. 

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